The lining of the uterus, the endometrium, undergoes continual remodelling throughout a woman’s reproductive years. During each menstrual cycle, the endometrium sheds and restores in preparation for implantation of the embryo, should conception occur. Disturbances to this remodelling can result in abnormal uterine bleeding, infertility, endometriosis, and endometrial cancer. The group aims to translate knowledge of endometrial repair and embryo implantation to provide treatments for uterine bleeding problems and improve success rates and long-term health outcomes for IVF. In a broader context, the team also hopes to apply knowledge of endometrial repair to help develop new ways to improve the treatment of chronic wounds and reduce scarring.
- Uterine fluid: the microenvironment of embryo implantation is critical for successful pregnancy
- Endometrial Repair
- Exosomes: a new paradigm for embryo-maternal interactions at implantation
Edgell TA (2018) Protein biomarkers of endometrial receptivity. In: Kovacs G and Salamonsen LA (eds). How to prepare the endometrium to maximise implantation rates and IVF success. Cambridge University Press.
Edgell TA, Evans J, Lazzaro L, Boyes K, Sridhar M, Catt S, Rombauts LJF, Vollenhoven BJ, Salamonsen LA (2018) Assessment of potential biomarkers of pre-receptive and receptive endometrium in uterine fluid and a functional evaluation of the potential role of CSF3 in fertility. Cytokine 111:222-229.
Fitzgerald HC, Evans J, Johnson N, Infusini G, Webb A, Rombauts LJR, Vollenhoven BJ, Salamonsen LA, Edgell TA (2018) Idiopathic infertility in women is associated with distinct changes in proliferative phase uterine fluid proteins. Biol Reprod. 98(6):752-764.
Van Sinderen M, Oyanedel J, Menkhorst E, Cuman C, Rainczuk K, Winship A, Salamonsen LA, Edgell TA, Dimitriadis E (2017) Soluble delta like Ligand 1 alters human endometrial epithelial cell adhesive capacity. Reprod Fertil Dev 29(4):694-702.
Fitzgerald HC, Salamonsen LA, Rombauts L, Vollenhoven B, Edgell TA (2016) The proliferative phase underpins endometrial development: altered cytokine profiles in uterine lavage fluid of women with idiopathic infertility. Cytokine 88:12-19.
Salamonsen LA, Evans J, Nguyen HPT, Edgell TA (2016) The microenvironment of human implantation: determinant of reproductive success. Amer J Reprod Immunol. 75(3):218-225. Review
Ng YH, Rome S, Jalabert A, Forterre A, Singh H, Hincks CL, Salamonsen LA (2013) Endometrial exosomes in the uterine microenvironment: a new paradigm for embryo-endometrial cross talk at implantation. PLOS One 8(3):e58502.
Edgell TA, Rombauts LJF, Salamonsen LA (2013) Assessing receptivity in the endometrium: the need for a rapid, non-invasive test. Reprod Biomed Online Reprod Biomed Online 27(5):486-96. doi: 10.1016/j.rbmo.2013.05.01.