Testicular cancer

The incidence of testicular cancer is rising worldwide at two per cent per year for the last 50 years, for unknown reasons. Younger men, aged between 20 and 40 years, have the highest risk of developing testicular cancer, the second most common cancer in this age group.

What is testicular cancer?

What causes testicular cancer?

How is testicular cancer diagnosed and treated?

Testicular cancer and male infertility

Our testicular cancer research

Discovering the processes required to make healthy sperm is essential knowledge for reversing the rising incidence of testicular cancer and infertility rates, and for developing treatments to combat these.

Understanding why disrupting testis development can increase testicular risk

Professor Kate Loveland from the Testis Development and Male Germ Cell Biology Research Group at Hudson Institute

Molecular studies. Professor Kate Loveland is identifying the windows of development, from fetal life through to puberty, in which male reproductive function can be affected by environmental exposures that have consequences which reduce adult male fertility or health.  The cells in a man’s testis that form one thousand sperm per heartbeat originate in the developing fetus and go through many transitions before they turn into swimming cells which can penetrate an egg and start a new life. The team’s research is uncovering the specific times and ways during transformation from a progenitor into a sperm when things can go wrong. In the case of testicular germ cell tumours, the first incidence occurs in the fetus, when something occurs to probably a few cells to stop them from maturing normally. They remain undetected until puberty when hormonal changes cause the cells to change into tumours.

Team | Professor Kate Loveland, Professor Mark Hedger, Associate Professor Patrick Western

Male fertility and testicular cancer

The yin and yang of testicular immune cells

The foundations of testis growth: Steroids in the fetal testis

Testicular cancer collaborators

Support for people with testicular cancer

Hudson Institute scientists cannot provide medical advice.
Find out more about testicular cancer.

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