The incidence of testicular cancer is rising worldwide at two per cent per year for the last 50 years, for unknown reasons. Younger men, aged between 20 and 40 years, have the highest risk of developing testicular cancer, the second most common cancer in this age group.
What is testicular cancer?
What causes testicular cancer?
How is testicular cancer diagnosed and treated?
Testicular cancer and male infertility
Our testicular cancer research
Discovering the processes required to make healthy sperm is essential knowledge for reversing the rising incidence of testicular cancer and infertility rates, and for developing treatments to combat these.
Understanding why disrupting testis development can increase testicular risk
Molecular studies. Professor Kate Loveland is identifying the windows of development, from fetal life through to puberty, in which male reproductive function can be affected by environmental exposures that have consequences which reduce adult male fertility or health. The cells in a man’s testis that form one thousand sperm per heartbeat originate in the developing fetus and go through many transitions before they turn into swimming cells which can penetrate an egg and start a new life. The team’s research is uncovering the specific times and ways during transformation from a progenitor into a sperm when things can go wrong. In the case of testicular germ cell tumours, the first incidence occurs in the fetus, when something occurs to probably a few cells to stop them from maturing normally. They remain undetected until puberty when hormonal changes cause the cells to change into tumours.
Male fertility and testicular cancer
The yin and yang of testicular immune cells
The foundations of testis growth: Steroids in the fetal testis
Testicular cancer collaborators
- Australian Urology Associates: Professor Mark Frydenberg
- Justus-Liebig University: Daniela Fietz
- Uniklinikum Giessen und Marburg: Hans-Christian Schuppe
- Peter MacCallum Cancer Centre: Ben Tran
- University of Utah: Jingtao Guo, Jim Hotaling
- University of Copenhagen: Ewa Rajpert-De Meyts, Kristian Almstrup, Anne Jorgensen
Support for people with testicular cancer
Hudson Institute scientists cannot provide medical advice.
Find out more about testicular cancer.
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