Dr Ruth Escalona is a member of the Centre for Reproductive Health.
Dr Ruth Escalona is an experienced cell and molecular biologist with a long-standing interest in understanding the molecular mechanisms of ovarian cancer spread. From 2001–2012 she was a Senior Research Assistant at Prince Henry’s Institute of Medical Research, Clayton, Australia, where she worked in the Ovarian Biology Group. From 2013–2014 she worked in the Ovarian Cancer Research Group in Women’s Cancer Research Centre, Royal Women’s Hospital, Melbourne led by Professor Nuzhat Ahmed, where she later undertook her PhD degree in the Department of Obstetrics and Gynecology, University of Melbourne, Australia. Dr Escalona’s thesis title was ‘The role of metzincins and TIMPs in ovarian cancer’. The aims of the project were to do a comprehensive analysis of genes involved in the TIMP pathway that are directly involved with cancer progression and chemoresistance using serous ovarian cancer tumours, ascites cells derived from patients and established ovarian cancer cell lines; to validate candidate gene associated regulatory pathways using siRNA and CRISPR methods, functional assays, and animal models. These studies have led to publications in reputable cancer journals.
Dr Escalona is now working as a Research Assistant for Fiona Elsey Cancer Research Institute, Ballarat, and holds an honorary position at the Centre for Reproductive Health, Hudson Institute of Medical Research, where she is currently based and continues her work in understanding the mechanisms of survival of ovarian cancer cells in response to chemotherapy treatment.