Patrick Western

Areas of interest

Research group

Biography

Co-Centre Head of the Centre for Endocrinology Reproductive Health at Hudson Institute of Medical Research, Professor Patrick Western’s research is focused on understanding the epigenetic processes underlying establishment of the germ cell lineage and the impact of transmitted epigenetic information on the next generation.

Professor Western completed his doctoral studies on temperature dependent sex determination in the American alligator. He then moved to Professor Azim Surani’s laboratory at the Wellcome Trust Gurdon Institute, Cambridge University, where he studied epigenetic reprogramming and the reacquisition of pluripotency in differentiated somatic cells, embryonic stem cells and germ cells.

Professor Western then joined the ARC Centre of Excellence in Biotechnology and Development where he pursued an interest in sex-specific germ cell development with a focus on the regulation of pluripotency and differentiation in early germ cells.

Prof Western leads the Germ Cell Development and Epigenetics Research group within the Centre for Endocrinology and Reproductive Health at Hudson Institute of Medical Research. Using genetic and pharmacological models, the Germ Cell Development and Epigenetics Research group studies mechanisms regulating epigenetic programming in the germline and the impacts of germline epigenetic information on offspring development. The work combines discovery science with translational research aimed at developing clinically relevant information required for understanding the impacts of epigenetic programming on disease inheritance, and the potential interactions between epigenomic drugs and the germline epigenome, and subsequent outcomes in offspring.

Student opportunities

Publication highlights

Edwards-Lee C, Jarred EG, Western PS (2025) Coordinated regulation of chromatin modifiers reflects organised epigenetic programming in mouse oocytes. Epigenetics & Chromatin. Apr 5;18(1):19. DOI:1186/s13072-025-00583-9.
Jarred EG, Western PS (2024) Polycomb in female reproductive health: patterning the present and programming the future. Reprod Fertil Dev. 2024 Dec;36:RD24152. doi: 10.1071/RD24152.
Blucher RO, Lim RS, Ritchie ME, Western PS (2024) VEGF-dependent testicular vascularisation involves MEK1/2 signalling and the essential angiogenesis factors, SOX7 and SOX17. BMC Biology. Oct 1;22(1):222. doi: 10.1186/s12915-024-02003-y.
Oberin R, Petautschnig S, Jarred EG, Qu Z, Tsai T, Youngson NA, Pulsoni G, Bildsoe H, Truong TT, Fernando D, Blucher RO, van den Buuse M, Gardner DK, Sims, NA, Adelson DL, Western PS (2024) Fetal growth delay caused by loss of non-canonical imprinting is resolved late in pregnancy and culminates in offspring overgrowth. eLife. May 30:13:e81875. doi: 10.7554/eLife.81875.
Blucher RO, Lim RS, Jarred EG, Ritchie ME, Western PS (2023) FGF-independent MEK1/2 signalling in the developing foetal testis is essential for male germline differentiation in mice. BMC Biol. 2023 Dec 5;21(1):281. doi: 10.1186/s12915-023-01777-x.
Jarred EG, Qu Z, Tsai T, Oberin R, Petautschnig S, Bildsoe H, Pederson S, Zhang QH, Stringer JM, Carroll J, Gardner DK, Van den Buuse M, Sims NA, Gibson WT, Adelson DL, Western PS (2022) Transient polycomb activity represses developmental genes in growing oocytes. Clin Epigenetics. 2022 Dec 21;14(1):183. doi: 10.1186/s13148-022-01400-w.
Prokopuk L, Jarred EG, Blücher RO, McLaughlin EA, Stringer JM, Western PS (2022) An essential role for Polycomb Repressive Complex 2 in the mouse ovary. Reproduction. 2022 Feb 17;163(3):167-182. doi: 10.1530/REP-21-0361.
Stringer JM, Western PS (2019) A step toward making human oocytes. Nat Biotechnol. Jan 3;37(1):24-25. doi: 10.1038/nbt.4329.
Jarred EG, Bildsoe H, Western PS (2018) Out of sight, out of mind? Germ cells and the potential impacts of epigenomic drugs. F1000Res Dec 21;7. pii:F1000 Faculty Rev-1967. doi: 10.12688/f1000research.15935.1. eCollection 2018.
Stringer JM, Forster SC, Qu Z, Prokopuk L, O’Bryan MK, Gardner DK, White SJ, Adelson D, Western PS (2018) Reduced PRC2 function alters male germline epigenetic programming and paternal inheritance. BMC Biol. Sep 20;16(1):104. doi: 10.1186/s12915-018-0569-5.
Prokopuk L, Stringer JM, White CR, Vossen RHAM, White SJ, Cohen ASA, Gibson WT, Western PS (2018) Loss of maternal EED results in postnatal overgrowth. Clin Epigenetics. Jul 13;10(1):95. doi: 10.1186/s13148-018-0526-8.
Prokopuk L, Hogg K, Western PS (2018) Pharmacological inhibition of EZH2 disrupts the female germline epigenome. Clin Epigenetics. Mar 5;10:33. doi: 10.1186/s13148-018-0465-4. eCollection 2018.
Western PS (2018) Epigenomic drugs and the germline: Collateral damage in the home of heritability? Mol Cell Endocrinol. Jun 15;468:121-133. doi: 10.1016/j.mce.2018.02.008. Epub 2018 Feb 19.
Prokopuk L, Stringer JM, Hogg K, Elgass KD, Western PS (2017) PRC2 is required for extensive reorganization of H3K27me3 during epigenetic reprogramming in mouse fetal germ cells. Epigenetics Chromatin. Feb 20:10:7. doi: 10.1186/s13072-017-0113-9. eCollection 2017.
Gustin SE, Stringer JM, Hogg K, Sinclair AH, Western PS (2016) FGF9, activin and TGFβ promote testicular characteristics in an XX gonad organ culture model. Reproduction. Nov;152(5):529-43. doi: 10.1530/REP-16-0293. Epub 2016 Aug 5.
Gustin SE, Hogg K, Stringer JM, Rastetter RH, Pelosi E, Miles DC, Sinclair AH, Wilhelm D, Western PS (2016) WNT/β-catenin and p27/FOXL2 differentially regulate supporting cell proliferation in the developing ovary. Dev Biol. Apr 15;412(2):250-60. doi: 10.1016/j.ydbio.2016.02.024. Epub 2016 Mar 3.
Hogg K, Western PS (2015) Refurbishing the germline epigenome: Out with the old, in with the new. Semin Cell Dev Biol. Sep;45:104-13. doi: 10.1016/j.semcdb.2015.09.012. Epub 2015 Oct 24.
Hogg K, Western PS (2015) Differentiation of fetal male germline and gonadal progenitor cells is disrupted in organ cultures containing knockout serum replacement. Stem Cells Dev. Dec 15;24(24):2899-911. doi: 10.1089/scd.2015.0196. Epub 2015 Sep 22.
Prokopuk L, Western PS, Stringer JM (2015) Transgenerational epigenetic inheritance: adaptation through the germline epigenome? Epigenomics. Aug;7(5):829-46. doi: 10.2217/epi.15.36. Epub 2015 Sep 14.
Stringer JM, Barrand S, Western P (2013) Fine-tuning evolution: germ-line epigenetics and inheritance. Reproduction. Jun 14;146(1):R37-48. doi: 10.1530/REP-12-0526. Print 2013 Jul.
Wakeling SI, Miles DC, Western PS (2013) Identifying disruptors of male germ cell development by small molecule screening in ex vivo gonad cultures. BMC Res Notes.Apr 30:6:168. doi: 10.1186/1756-0500-6-168.
Miles DC, Wakeling SI, Stringer JM, van den Bergen JA, Wilhelm D, Sinclair AH, Western PS (2013) Signaling through the TGF beta-activin receptors ALK4/5/7 regulates testis formation and male germ cell development. PLoS One. 8(1):e54606. doi: 10.1371/journal.pone.0054606. Epub 2013 Jan 16.
Google Scholar Citations: http://scholar.google.com.au/citations?user=igBeqKUAAAAJ

Professor Patrick Western

Areas of interest

Research group

Biography

Student opportunities

Publication highlights

Life as an explorer: mentors in science

Non-genetic disease inheritance – reading between the genes

Big ideas attract big funding

ARC Discovery Projects success

Male health at conception could impact child health

Inheritance—new anti-cancer medication may affect offspring

Stunning NHMRC Grant success

Professor Patrick Western

Areas of interest

Research group

Biography

Student opportunities

Publication highlights

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