My research focuses on molecular genetics to investigate three areas of human sexual differentiation where perturbation leads to disease: disorders of sex development (DSD), gender bias in neurological disease susceptibility (such as Parkinson’s disease, ADHD and schizophrenia) and gender dysphoria.

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Professor Vincent Harley - 2018 NHMRC Fellowship success

Areas of interest

Intersex conditions

Research group

Sex Development


Professor Vincent Harley leads the Sex Determination and Gonadal Development Research Group in the Centre for Endocrinology and Metabolism. He previously held positions in the UK (Imperial Cancer Research Fund Laboratories, London, and Department of Genetics at Cambridge University) and at the Howard Florey Institute in Melbourne, before joining the Prince Henry’s Institute, now Hudson Institute of Medical Research, in 2000.

Prof Harley’s research focuses on transcription factors and their role in health and disease, with a particular focus on the sex determining gene, SRY, and its contribution to sex (male) bias in certain neurological disorders, such as Parkinson’s disease, ADHD and schizophrenia. A second research aim is to establish the biological basis for gender identity through genetic analyses of transgender individuals.

His expertise lies in molecular genetics, sex differentiation, organ development and gene regulation.

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