The Immunohaematology research group are interested in signalling pathways that control homeostasis and function of blood and immune cells in health and disease.

Specific research interests are

• Defining the roles of the NFκB signalling pathway in lymphocyte development and function;
• Modulation of iron in disorders of ineffective erythropoiesis;
• Targeting the NFκB pathway in haematological neoplasms.

Research Group

• Dr Raffi Gugasyan, Honorary Research Associate
• Shahla Vilcassim, PhD Student

Selected publications

• Banerjee A, Mifsud N, Bird R, Forsyth C, Szer J, Tam C, Kellner S, Grigg A, Motum P, Bentley M, Opat S, Grigoriadis G (2015) The oral iron chelator deferasirox inhibits NF-κB mediated gene expression without impacting on proximal activation: Implications for myelodysplasia and aplastic anaemia. Br J Haematol 168:576-82.

• de Valle E, Grigoriadis G, O’Reilly L, Willis S, Lin A, Maxwell M, Corcoran L, Tsantikos E, Kirsten Fairfax K, Hibbs B, Vasanthakumar A, Febbraio M, Hibbs M, Pellegrini M, Banerjee A, Kallies A, MacKay F, Strasser A, Gerondakis S, Gugasyan R (2016) NFκB1 prevents the development of multi-organ autoimmunity by controlling IL-6 production in Follicular B cells. J Exp Med 213:621-41.

• Talaulikar D, Tam CS, Joshua D, Ho JP, Szer J, Quach H, Spencer A, Harrison S, Mollee P, Roberts AW, Horvath N, Lee C, Zannettino A, Brown R, Augustson B, Jaksic W, Gibson J, Kalff A, Johnston A, Trotman J, Kalro A, Grigoriadis G, Ward C, Prince HM (2017) Treatment of patients with Waldenström macroglobulinaemia: clinical practice guidelines from the Myeloma Foundation of Australia Medical and Scientific Advisory Group. Intern Med J 47:35-49.

• Thubthed R, Siriworadetkun S, Paiboonsukwong K, Fucharoen S, Pattanapanyasat K, Vadolas J, Svasti S, Chaichompoo P (2022) Impaired neutrophil extracellular trap formation in β-thalassaemia/HbE. Sci Rep, 12:1967.