Dr Kallyanashis Paul is a post-doctoral researcher in the Translational Tissue Engineering lab. Dr Paul received his PhD from Monash University in the Department of Obstetrics and Gynaecology. He demonstrated a versatile bio-manufacturing skill set learned through his bachelor’s study in Industrial and Production Engineering, Bangladesh followed by industrial work experience (5 years+) and a master’s study in Regenerative Bone Tissue Engineering (South Korea). So far, he reported 7 distinct prototypes to solve some critical health burdens for the aged people including pelvic organ prolapse (POP), osteoporosis, and large segmental bone defect. His PhD research demonstrated the world’s first proof of concept of developing customised therapeutics for treating POP at its earlier and chronic stage, which was nominated in the finalist round under the clinical researcher category of the Prestigious Victorian Premier’s Awards for Health and Medical Research. He received a Veski (Victoria) fellowship to augment his translational research skill in 3D printing.

His current research focuses on cross-disciplinary tissue engineering treatments for POP involving 3D printing of degradable polymers and therapeutic cells to embed physical/topographic cues such as angular orientation or pore size to direct the cellular function favourably. Additionally, he is interested in improving the repeatability and scalability of the research work to outreach the clinical translation towards a social impact.

Selected publications

• K. Paul, S. Darzi, G. McPhee, M.P. Del Borgo, J.A. Werkmeister, C.E. Gargett, S. Mukherjee, 3D bioprinted endometrial stem cells on melt electrospun poly ε-caprolactone mesh for pelvic floor application promote anti-inflammatory responses in mice, Acta Biomaterialia 97 (2019) 162-176.

• K. Paul, S. Darzi, M.P. Del Borgo, F.L. Cousins, J.A. Werkmeister, C.E. Gargett, S. Mukherjee, Vaginal delivery of tissue engineered endometrial mesenchymal stem/stromal cells in an aloe vera-alginate hydrogel alleviates maternal simulated birth injury, Applied Materials Today. 22 (2020), 100890

• K. Paul, S. Darzi, J.A. Werkmeister, C.E. Gargett, S. Mukherjee. Emerging Nano/Micro-Structured Degradable Polymeric Meshes for Pelvic Floor Reconstruction. Nanomaterials (2020), 10 (6):1120.

• S. Darzi *, K. Paul *, S Leitan, J.A. Werkmeister, C.E. Gargett, S. Mukherjee, Immunobiology and Application of Aloe Vera-based Scaffolds in Tissue Engineering, International Journal of Molecular Sciences. (2021), 22(4):1708.

• K. Paul, B.Y. Lee, C. Abueva, B. Kim, H.J. Choi, S.H. Bae, B.T. Lee, In vivo evaluation of injectable calcium phosphate cement composed of Zn-and Si-incorporated β-tricalcium phosphate and monocalcium phosphate monohydrate for a critical-sized defect of the rabbit femoral condyle, Journal of Biomedical Materials Research Part B: Applied Biomaterials 105(2) (2017) 260-271

• K. Paul, A.R. Padalhin, N.T.B. Linh, B. Kim, S.K. Sarkar, B.T. Lee, A study of BMP-2-loaded bipotential electrolytic complex around a biphasic calcium phosphate-derived (BCP) scaffold for repair of large segmental bone defect, PloS one 11(10) (2016) e0163708

• J. Amirian, P. Makkar, G.H. Lee, K. Paul, B.T. Lee, Incorporation of alginate-hyaluronic acid microbeads in injectable calcium phosphate cement for improved bone regeneration, Materials Letters 272 (2020) 127830.