Dr Chunhua (Nick) Wan is a member of the Cancer Genetics and Functional Genomics Research group in the Centre for Cancer Research.

Learn more about my group's research

Dr Chunhua (Nick) Wan is a member of the Cancer Genetics and Functional Genomics Research group in the Centre for Cancer Research.

Areas of interest

Bowel cancer Childhood cancer Necrotising enterocolitis (NEC)

Research group

Cancer Genetics and Functional Genomics

Biography

Dr Chunhua (Nick) Wan mainly employs genome-scale CRISPR-Cas9 loss-of-function screening to investigate Wnt/β-catenin pathway, a central pathway leading to colorectal cancer initiation and progression. Using this technique, we may clarify the mechanism underlying Wnt/β-catenin signaling transduction in whole human genome, and identify novel therapy targets for colorectal cancer.

Dr Wan finished his PhD in the Department of Biochemistry and Molecular Biology at Peking Union Medical College of Tsinghua University, China, in 2011, where he investigated the function of a Rhomboid intramembrane protease and its role in colorectal cancer development.

Publication highlights