Tumour microenvironment and metabolic plasticity in cancer and cancer stem cells

Lead researcher

Professor Nuzhat Ahmed

Main finding

This review article covered massive literature on the effect of tumour microenvironment in changing the metabolic features of tumour cells, especially in the context of changed microenvironment in response to drug treatment.

Centre

Centre for Reproductive Health

Research group

Ovarian Biology

Co-authors

Ms Ruth Escalona
Dr Dilys Leung
Ms Emily Chen
Professor George Kannourakis

Journal and article title

Seminars in Cancer Biology

Tumour microenvironment and metabolic plasticity in cancer and cancer
stem cells: Perspectives on metabolic and immune regulatory signatures in
chemoresistant ovarian cancer stem cells

Most surprising

The novelty of this article is the demonstration of a immunoregulatory signature in chemoresistant ovarian cancer cells collected from patients.

Future implications

This research will help in understanding the chemoresistant features of ovarian cancer cells.

Disease/health impact

Ovarian Cancer