Lead researcher
Dr Virginie Deswaerte
Main finding
This review highlights recent advancements in our understanding of the transcriptional regulation of genes encoding inflammasome- associated innate immune receptors, and the impact on a variety of cellular responses during disease pathogenesis.
Centre
Centre for Innate Immunity & Infectious Diseases
Research group
Cancer and Immune Signalling Laboratory
Journal and article title
Most surprising
The dysregulated expression and/or activation of inflammasomes is increasingly implicated in numerous disease states, such as chronic auto-inflammatory and autoimmune disorders, metabolic syndrome, neurodegenerative and cardiovascular diseases, as well as cancer.
Future implications
A better understanding of the mechanisms regulating the inflammasome, and the involvement of such mechanisms in the pathogenesis of human diseases, has potential to assist the development of novel targeted treatments.
Disease/health impact
Multiple diseases