Lead researcher
Dr Quynh-Nhu Nguyen, PhD student, University of Melbourne,
Main finding
These studies identify a compound in the cell death pathway responsible for depletion of eggs in the ovarian reserve following exposure to cyclophosphamide or cisplatin
Centre
Centre for Reproductive Health
Research group
Ovarian biology
Journal and article title
Most surprising
There were mechanistic differences in the death of eggs and depletion of the ovarian reserve in response to these different chemotherapies.
Future implications
Targetted inhibition of PUMA, the compound responsible for the death of eggs may be an effective ovarian-protective strategy during cancer treatment in women.
Disease/health impact
Ovarian cancer
