Dr Quynh-Nhu Nguyen, PhD student, University of Melbourne,
These studies identify a compound in the cell death pathway responsible for depletion of eggs in the ovarian reserve following exposure to cyclophosphamide or cisplatin
Centre for Reproductive Health
Journal and article title
There were mechanistic differences in the death of eggs and depletion of the ovarian reserve in response to these different chemotherapies.
Targetted inhibition of PUMA, the compound responsible for the death of eggs may be an effective ovarian-protective strategy during cancer treatment in women.