Ms Ruth M Escalona
The metzincin family of metalloproteinases consists of enzymes involved in matrix remodeling in response to normal physiological changes and diseased states. This review investigates the role of metzincins and their inhibitors in cancer progression with a focus on ovarian cancer.
Centre for Reproductive Health
Journal and article title
There is sufficient evidence in the published literature to warrant an investigation of the role of metzincins and their inhibitors in ovarian cancer.
We propose that understanding the metzincins and their inhibitor biology in ovarian cancer may provide valuable insights in combating ovarian cancer progression and chemoresistance-mediated recurrence in patients.