Lead researcher
Dr Saeedeh Darzi
Main finding
1. endometrial mesenchymal stem cells change the macrophage phenotype from M1( Inflammatory) to M2 (anti-inflammatory)
2. endometrial mesenchymal stem cells reduce the inflammatory cytokine secretion in macrophages (less inflammation)
3. endometrial mesenchymal stem cells up-regulate the M2 macrophages markers ( improve healing and regeneration)
Centre
The Ritchie Centre
Research group
endometrial stem cell biology group
Journal and article title
Most surprising
Differences in the immune status in the two animals directly affect the survival of eMSC which leads to
differences in the short-term and long-term macrophage responses to implanted meshes
Future implications
our research will benefit women who are suffering from the complications associated with vaginal mesh surgery and benefit their families, employers and healthcare system.
Disease/health impact
Pelvic Organ Prolapse treatment