Dr Virginie Deswaerte
We found a novel pro-tumorigenic ASC/IL-18/NF-κB signaling axis which augments gastric epithelial cell survival in gastric cancer.
Centre for Innate Immunity & Infectious Diseases
Cancer and Immune Signalling
Journal and article title
We reveal a pro-tumorigenic role for ASC in gastric cancer and tissue-specific activities of IL-18.
Given the fact that gastric cancer is the third most common causes of cancer death worldwide and the current lack of curative treatment, therapies that neutralize the biological activity of IL-18 may serve as effective weapons against this form of cancer.