Call to set up neonatal uterine bleeding register to monitor early onset endometriosis

Lead researcher

Associate Professor Caroline Gargett

Main finding

On the basis of re-examining old literature in the light of new discoveries such as endometrial stem/progenitor cells, this paper proposes that neonatal uterine bleeding which occurs in 5% of baby girls in the first week of life should be recorded so that prospective studies can be done to examine its links with reproductive disorders such as endometriosis.


The Ritchie Centre

Research group

Endometrial Stem Cell Biology


Dr Patrick Puttermans, Prof Giuseppe Benagiano, A/Prof Caroline Gargett, Prof Robert Romero, Prof Sun Wei Guo, Prof Ivo Brosens

Journal and article title

Most surprising

A simple clinical observation - neonatal uterine bleeding - now regarded as inconsequential and ignored, could be a non-invasive biomarker for the development of the most severe forms of endometriosis in young girls as they reach puberty.

Future implications

Adolescent endometriosis normally takes 6-11 years to diagnose and neonatal uterine bleeding may lead to a more rapid diagnosis and hence earlier and more effective treatment. This could prevent many lost days of school and much pain for young girls, improving their quality of life and potentially protecting their fertility as 50% of women with endometriosis are infertile.

Disease/health impact

Early Onset Endometriosis

Other points of interest

We believe we have worked out a way of collecting data on neonatal uterine bleeding using social media and iPhones. Also, we are planning to develop an animal model of neonatal uterine bleeding in menstruating mice to determine if it causes endometriosis.