Professor Lois Salamonsen
This invited review, firstly defines the different forms of extracellular vesicles (EVs), their purification and validation. EVs (including exosomes) package distinct cargo elements that vary depending upon cell of origin and its phenotype. EVs are present in the uterine cavity, with demonstrated effects on in the microenvironment of sperm transport and of blastocyst and endometrial preparation for implantation. Importantly, uptake of endometrial exosomes by blastocysts, alters trophectodermal implantation potential.
Centre for Reproductive Health
Journal and article title
This is an emerging field and the review is timely.
The findings confirm the importance of the intrauterine microenvironment for successful implantation and define a role for locally released exosomes in establishing a pregnancy.
Other points of interest
We have established an active exosome interest group at the Hudson and would welcome further members.