Lead researcher
Professor Lois Salamonsen
Main finding
This invited review, firstly defines the different forms of extracellular vesicles (EVs), their purification and validation. EVs (including exosomes) package distinct cargo elements that vary depending upon cell of origin and its phenotype. EVs are present in the uterine cavity, with demonstrated effects on in the microenvironment of sperm transport and of blastocyst and endometrial preparation for implantation. Importantly, uptake of endometrial exosomes by blastocysts, alters trophectodermal implantation potential.
Centre
Centre for Reproductive Health
Research group
Endometrial remodelling
Journal and article title
Most surprising
This is an emerging field and the review is timely.
Future implications
The findings confirm the importance of the intrauterine microenvironment for successful implantation and define a role for locally released exosomes in establishing a pregnancy.
Disease/health impact
Fertility/ infertility
Other points of interest
We have established an active exosome interest group at the Hudson and would welcome further members.
