- Role: Postdoctoral ScientistGroup: Ovarian Cancer Biomarkers
Dr Yiqian Chen is a Postdoctoral Scientist within the Ovarian Cancer Biomarkers Research Group. Yiqian is working on the Invion Limited-sponsored research project to advance Invion’s cancer treatment technology, PhotosoftTM. Photosoft™ is a next generation Photodynamic Therapy (PDT). PDT is a minimally invasive therapeutic treatment that uses non-toxic photosensitisers and visible light in combination with oxygen to produce cytotoxic Reactive Oxygen Species (ROS) with the aim of killing malignant cells and stimulating the immune system.
Chen Y, Gall MG, Zhang H, Keane FM, McCaughan GW, Yu DM, Gorrell MD (2016) Dipeptidyl peptidase 9 enzymatic activity influences the expression of neonatal metabolic genes. Exp Cell Res 342:72-82.
Zhang H, Chen Y, Wadham C, McCaughan GW, Keane FM, Gorrell MD (2015) Dipeptidyl peptidase 9 subcellular localization and a role in cell adhesion involving focal adhesion kinase and paxillin. Biochim Biophys Acta 1853:470-480.
Osborne B, Yao TW, Wang XM, Chen Y, Kotan LD, Nadvi NA, Herdem M, McCaughan GW, Allen JD, Yu DMT, Topaloglu AK, Gorrell MD (2014) A rare variant in human fibroblast activation protein associated with ER stress, loss of enzymatic function and loss of cell surface localisation. Biochim Biophys Acta 1844:1248-1259.
Gall MG, Chen Y, Ribeiro AJV, Zhang H, Bailey CG, Spielman DS, Yu DMT, Gorrell MD (2013) Targeted inactivation of dipeptidyl peptidase 9 enzymatic activity causes mouse neonate lethality. PLoS One 8:e78378.
Zhang H, Chen Y, Keane FM, Gorrell MD (2013) Advances in understanding the expression and function of dipeptidyl peptidase 8 and 9. Mol Cancer Res 11:1487-1496.
Chowdhury S, Chen Y, Yao TW, Ajami K, Wang XM, Popov Y, Schuppan D, Bertolino P, McCaughan GW, Yu DMT, Gorrell MD (2013) Regulation of dipeptidyl peptidase 8 and 9 expression in activated lymphocytes and injured liver. World J Gastroenterol 19:2883-2893.