Shouya Feng

Areas of interest

Gastroenteritis Inflammation and cancer Inflammatory bowel disease (IBD) Lupus

Research group

Innate Immune and Autoinflammatory Disease

Biography

Dr Shouya Feng is a postdoctoral scientist in the fields of inflammasomes and autoinflammatory diseases. She completed her PhD in Innate Immunology at the Australian National University in 2023 under the supervision of Professor Si Ming Man. In 2022, Dr Feng joined the Masters lab in the Inflammation Division at WEHI. In 2024, Dr Feng joined the Innate Immune and Autoinflammatory Disease group at Hudson Insitute with Professor Seth Masters.

Dr Feng’s research aims to understand the mechanisms of inflammasome regulation and how this can be harnessed to treat autoinflammatory diseases. Her current studies investigate the pathogenicity of mutations in inflammasome sensors and regulators identified from patients with autoinflammatory diseases.

Education

Publication highlights

Pandey A, Shen C, Feng S, Enosi Tuipulotu D, Ngo C, Liu C, Kurera M, Mathur A, Venkataraman S, Zhang J, Talaulikar D, Song R, Wong JJ, Teoh N, Kaakoush NO, Man SM (2024) Ku70 senses cytosolic DNA and assembles a tumor-suppressive signalosome. Sci Adv 10(4):eadh3409.
Tuipulotu DE *, Feng S *, Pandey A, Zhao A, Ngo C, Mathur A, Lee J, Shen C, Fox D, Xue Y, Kay C, Kirkby M, Lo Pilato J, Kaakoush NO, Webb W, Rug M, Robertson AAB, Tessema MB, Pang S, Degrandi D, Pfeffer K, Augustyniak D, Blumenthal A, Miosge LA, Brüstle A, Yamamoto M, Reading PC, Burgio G, Man SM (2023) Immunity against Moraxella catarrhalis requires guanylate-binding proteins and caspase-11-NLRP3 inflammasomes. EMBO journal 15;42(6):e112558. *Equal authors.
Feng S *,Tuipulotu DE *, Pandey A, Jing W, Shen C, Ngo C, Tessema MB, Li FJ, Fox D, Mathur A, Zhao A, Wang R, Pfeffer K, Degrandi D, Yamamoto M, Reading PC, Burgio G, Man SM (2022) Pathogen-selective killing by guanylate-binding proteins as a molecular mechanism leading to inflammasome signaling. Nature Communications 13, 4395. *Equal authors.
Jing W, Lo Pilato J, Kay C, Feng S, Tuipulotu, DE, Mathur A, Shen C, Zhao A, Miosge L, Ali S, Gardiner E, Awad M, Lyras D, Robertson A, Kaakoush NO, Man SM (2022) Clostridium septicum α-toxin activates the NLRP3 inflammasome by engaging GPI-anchored proteins. Science Immunology, 7(71): eabm1803.
Jing W, Lo Pilato J, Kay C, Feng S, Tuipulotu, DE, Mathur A, Shen C, Zhao A, Miosge L, Ali S, Gardiner E, Awad M, Lyras D, Robertson A, Kaakoush NO, Man SM (2022) Clostridium septicum α-toxin activates the NLRP3 inflammasome by engaging GPI-anchored proteins. Science Immunology, 7(71): eabm1803.
Feng S, Man SM (2020) Captain GBP1: inflammasomes assemble, pyroptotic endgame. Nature Immunology 21(8): 829-830.
Mathur A, Feng S, Hayward JA, Ngo C, Fox D, Atmosukarto II, Price JD, Schauer K, Märtlbauer E, Robertson AAB, Burgio G, Fox EM, Leppla SH, Kaakoush NO, Man SM (2019) A multicomponent toxin from Bacillus cereus incites inflammation and shapes host outcome via the NLRP3 inflammasome. Nat Microbiol 4(2):362-374
Feng S, Fox D, Man SM (2018) Mechanisms of Gasdermin Family Members in Inflammasome Signaling and Cell Death. J Mol Biol 430(18 Pt B):3068-3080.

Dr Shouya Feng

Areas of interest

Research group

Biography

Education

Publication highlights

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