Dr Shayanti Mukherjee is Research Scientist in the Women’s health theme at The Ritchie Centre. She completed her PhD at the National University of Singapore where her work contributed to the growing body of nanostructured biomaterials design for repair and regeneration of soft tissues. Her research encompasses principles of material science, nanotechnology, stem cell biology and immunology to improve maternal urogynecological health.

Currently, her work involves design of optimal meshes using degradable polymers and additives for improving the treatment of pelvic organ prolapse. Dr Mukherjee and her team have designed novel tissue engineered stem cell based surgical constructs using solution electrospinning, 3D Printing and Melt electro writing. She also has a keen interest in bio-inks for stem cell bioprinting for personalising pelvic floor reconstructive surgery. Dr Mukherjee has a strong interest in biomaterial induced immune response and is an expert in evaluation of foreign body response using small and large animal models. The multi-dimensional research led by Dr Mukherjee aims to improve the understanding of the fundamental pelvic muscle physiology as well as accelerate the clinical translation new generation of surgical constructs for urogynecology.

Students with good academic records and interest in challenging multi-disciplinary tissue engineering and nanomaterials projects may enquire for PhD and other research project opportunities.

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Selected publications

• Paul K, Darzi S, Werkmeister JA, Gargett CE, Mukherjee S (2020). Emerging Nano/Micro-Structured Degradable Polymeric Meshes for Pelvic Floor Reconstruction. Nanomaterials (Basel), 2020. 10(6).

• Góra A, Tian L, Ramakrishna S, Mukherjee S (2020). Design of Novel Perovskite-Based Polymeric Poly(l-Lactide-Co-Glycolide) Nanofibers with Anti-Microbial Properties for Tissue Engineering. Nanomaterials (Basel), 2020. 10(6).

• Mukherjee S, Darzi S, Paul K, Cousins FL, Werkmeister JA, Gargett CE (2020). Electrospun Nanofiber Meshes With Endometrial MSCs Modulate Foreign Body Response by Increased Angiogenesis, Matrix Synthesis, and Anti-Inflammatory Gene Expression in Mice: Implication in Pelvic Floor. Frontiers in Pharmacology, 2020. 11(353).

• Welch NG , Mukherjee S , Hossain MA, Praveen P, Werkmeister JA, Wade JD,  Bathgate RAD, Winkler DA, Thissen H. (2019) Coatings Releasing the Relaxin Peptide Analogue B7-33 Reduce Fibrotic Encapsulation. ACS Appl Mater Interfaces, 2019. 11(49): p. 45511-45519.

• Paul K, Darzi S, McPhee G, Del Borgo MP, Werkmeister JA, Gargett CE, Mukherjee S (2019) 3D bioprinted endometrial stem cells on melt electrospun poly ε-caprolactone mesh for pelvic floor application promote anti-inflammatory responses in mice. Acta Biomaterialia S1742-7061(19)30550-1. 

• Mukherjee S, Darzi S, Troung Y, Kadam V, Rosamilia A, Werkmeister J and Gargett C (2019) Blended Nanostructured Degradable Mesh with Endometrial Mesenchymal Stem Cells Promotes Tissue Integration and Anti-Inflammatory Response in Vivo for Pelvic Floor Application. Biomacromolecules 20 (1), pp 454–468.

• Emmerson S, Mukherjee S, Melendez J, Cousins F, Edwards SL, Karjalainen P, Ng M, Tan, KS, Darzi S, Bhakoo K, Rosamilia A , Werkmeister JA, Gargett CE (2019) Composite mesh design for delivery of autologous mesenchymal stem cells influences mesh integration, exposure and biocompatibility in an ovine model of pelvic organ prolapse. Biomaterials.

• Mukherjee S, Darzi S, Paul K, Werkmeister JA, Gargett CE (2019) Mesenchymal stem cell-based bioengineered constructs: foreign body response, cross-talk with macrophages and impact of biomaterial design strategies for pelvic floor disorders. Interface Focus 6;9(4):20180089

• Parkinson LA, Rosamilia A, Mukherjee S, Papageorgiou AW, Melendez-Munoz J, Werkmeister JA, Gargett CE, Arkwright JW (2019) A fiber-optic sensor-based device for the measurement of vaginal integrity in women.  Neurourol Urodyn.

• S Darzi, J Deane, C Nold, S Edwards, D Gough, S Mukherjee, S Gurung, K Tan, A Vashi, J Werkmeister, and C Gargett (2018) Endometrial Mesenchymal Stem/Stromal Cells Modulate the Macrophage Response to Implanted Polyamide/Gelatin Composite Mesh in Immunocompromised and Immunocompetent Mice. Scientific Reports 8, Article number: 6554 (Q1)

• C Gargett, S Gurung, S Darzi, J Werkmeister and S Mukherjee (2019) Tissue engineering approaches for treating pelvic organ prolapse using a novel source of stem/stromal cells and new materials. Current Opinion in Urology.

• H Liu, S Mukherjee, J Kan, Y Liu, S Ramakrishna (2018) Recent studies on electrospinning preparation of patterned, core-shell and aligned scaffolds. Journal of Applied Polymer Science 135 (31), 46570.(Q2)

• Kadam V, Truong Y, Easton C, Mukherjee S, Wang L, Padhye R, Kyratzis I (2018). Electrospun Polyacrylonitrile/β–Cyclodextrin Composite Nanofiber Membranes for Simultaneous Air filtration and Gas adsorption. ACS Applied Nano Materials 1 (8), 4268-4277.