Biography
Dr Ruby Dawson’s work focusses on the roles of innate immune sensors in the development of gastric cancer and Helicobacter-induced gastric inflammation.
Since completing her PhD at the University of Adelaide, Ruby has published two first-author papers in the prestigious Gut journal and Immunology and Cell Biology, which investigate the role of the innate immune DNA sensor, AIM2, in gastric inflammation and tumorigenesis. She also has co-authorship on manuscripts in other reputable journals which investigate mechanisms of gastric cancer, a review on IL-6 family cytokines (Cytokine) and a book chapter based on the innate immune system in gastric cancer that is part of book series entitled “Research and Clinical Applications of Targeting Gastric Neoplasms” (Elsevier).
Ruby is active in the wider scientific community as an elected council member of the International Cytokine and Interferon Society (ICIS) and an ECR representative on the Victorian Infection and Immunity Network (VIIN) Young Investigator Committee.
Publication highlights
Dawson R, Deswaerte V, Sun E, West A, Ferrero R, Jenkins BJ. (2023) The cytosolic DNA sensor AIM2 promotes Helicobacter-induced gastric pathology via the inflammasome. Immunol Cell Biol).
Tang K, McLeod L, Livis T, West A, Dawson R, Yu L, Balic J, Chonwerawong M, Wray-McCann G, Oshima H, Oshima M, Deswaerte V, Ferrero R, Jenkins B. (2022) Toll-like receptor 9 promotes initiation of gastric tumorigenesis by augmenting inflammation and cellular proliferation. Cell. Mol. Gastroenterol. Hepatol.
Dawson R, Deswaerte V, West A, Tang K, West A, Balic J, Gearing L, Saad M, Yu L, Wu Y, Bhathal P, Kumar B, Chakrabarti J, Zavros Y, Oshima H, Kilnman D, Oshima M, Tan P, Jenkins BJ. (2021) STAT3-mediated upregulation of the AIM2 DNA sensor links innate immunity with cell migration to promote epithelial tumorigenesis. Gut. 2020–323916
Dawson R, Jenkins BJ, Saad M. (2021) IL-6 family cytokines in respiratory health and disease. Cytokine. 143:155520
Dawson R, Jenkins J (2021) Unravelling the pro-tumorigenic role of innate immune pattern recognition receptors in the gastric compartment. Research and Clinical Applications of Targeting Gastric Neoplasms. Ed. Jenkins, BJ. Elsevier.
Balic J, Saad M, Dawson R, West A, West A, D’Costa K, Deswaerte V, McLeod L, Dev A, Gough D, Bhathal P, Ferrero R, Jenkins B (2020) Constitutive STAT3 serine phosphorylation promotes Helicobacter-mediated gastric disease. Am J Pathol. 190:1256-1270.
