- Role: Postdoctoral ScientistGroup: Cancer Genetics and Functional Genomics
Dr Madara Ratnadiwakara is a post-doctoral scientist working in the Cancer Genetics and Functional Genomics lab led by Professor Ron Firestein.
Dr Ratnadiwakara completed her PhD in 2015 at the John Curtin School of Medical Research- Australian National University under the supervision of Associate Professor Anneke Blackburn. She then joined the Laboratory of Dr Minni Änkö at the Monash University in 2016 as a post-doctoral research fellow. With the relocation of the laboratory, she joined Hudson Institute of Medical Research in 2018 and moved to the Cancer Genetics and Functional Genomics lab in 2022.
Dr Ratnadiwakara’s current research focuses mainly on the role or RNA binding proteins in regulating RNA processing machinaries during early development and cancer.
Heazlewood S, Ahmad T, Mohenska M, Guo BB, Gangatirkar P, Josefsson EC, Ellis S, Ratnadiwakara M, Cao H, Cao B, Heazlewood C, Williams B, Fulton M, White J, Ramialison M, Nilsson SK, Anko ML (2021) RNA Binding Protein SRSF3 confers an essential role in megakaryocyte maturation and platelet production. Blood Dec 1:blood.2021013826. doi: 10.1182/blood.2021013826. Epub ahead of print.
Vandestadt C, Vanwalleghem GC, Khabooshan MA, Douek AM, Castillo HA, Li M, Schulze K, Don E, Stamatis SA, Ratnadiwakara M, Änkö ML, Scott EK, Kaslin J (2021) RNA-induced inflammation and migration of precursor neurons initiates neuronal circuit regeneration in zebrafish. Dev Cell 56(16):2364-2380.
Ratnadiwakara M, Engel R, Jarde T, McMurrick PJ, Abud HE, Anko ML (2019) SRSF3 confers selective processing of miR-17-92 cluster to promote tumorigenic properties in colorectal cancer. bioRxiv doi: https://doi.org/10.1101/667295
Ratnadiwakara M, Rooke M, Ohms SJ, French HJ, Williams RBH, Li RW, Zhang D, Lucas RM, Blackburn AC (2019) The SuprMam1 breast cancer susceptibility locus disrupts the vitamin D/ calcium/ parathyroid hormone pathway and alters bone structure in congenic mice. J Steroid Biochem Mol Biol 188:48-58.
Ratnadiwakara M, Archer SK, Dent CI, Ruiz De Los Mozos I, Beilharz TH, Knaupp AS, Nefzger CM, Polo JM, Anko ML (2018) SRSF3 promotes pluripotency through Nanog mRNA export and coordination of the pluripotency gene expression program. Elife 7:e37419.
Ratnadiwakara M, Änkö ML (2018) RNA Immunoprecipitation Assay to Determine the Specificity of SRSF3 Binding to Nanog mRNA. Bio Protoc 8(21):e3071.
Ratnadiwakara M, Änkö ML (2018) mRNA Stability Assay Using transcription inhibition by Actinomycin D in Mouse Pluripotent Stem Cells. Bio Protoc 8(21):e3072.
Ratnadiwakara M, Mohenska M, Änkö ML (2018) Splicing factors as regulators of miRNA biogenesis – links to human disease. Semin Cell Dev Biol 79:113-122.