Role of cancer stem cells in tumour progression
Cancer “stem cells” are hypothesised to control multiple aspects of tumour behaviour, including progression, recurrence and clinical response to therapy. Therapies designed to eliminate the CSC subset are likely to be key in achieving effective, sustained remission.
We have identified a key population of stem-like cells in ovarian cancer that control the invasive behaviour of ovarian cancers in vitro and in vivo. This project is focused on understanding the molecular nature of these cells, and the pre-clinical development of a novel monoclonal antibody therapy for directed tumour regression.