Project Leader

• Dr Matthew McKenzie

Mitochondria generate most of the energy needed for normal cell function, however how the cell controls this process is largely unknown. This project will examine how microRNAs control mitochondrial metabolism and how this regulation is coordinated with other functions within the cell. It will utilize techniques such as Blue Native–PAGE, transfection of mammalian cells with synthetic microRNAs and quantitative real-time PCR to examine how microRNAs coordinate mitochondrial metabolism with the regulation of global cell function.