MicroRNA regulation of mitochondrial function
MicroRNA regulation of mitochondrial function is a Research Project for the Archived: Molecular Basis of Mitochondrial Disease Research Group, under the Centre for Innate Immunity and Infectious Diseases.
Mitochondria generate most of the energy needed for normal cell function, however how the cell controls this process is largely unknown. This project will examine how microRNAs control mitochondrial metabolism and how this regulation is coordinated with other functions within the cell. It will utilize techniques such as Blue Native–PAGE, transfection of mammalian cells with synthetic microRNAs and quantitative real-time PCR to examine how microRNAs coordinate mitochondrial metabolism with the regulation of global cell function.